Dendrimer-based nanoprobe for dual modality magnetic resonance and fluorescence imaging.
basic_science · Level V
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Abstract
A novel PAMAM dendrimer-based nanoprobe for dual magnetic resonance and fluorescence imaging modalities was synthesized. Fluorescence studies revealed that Gd(III) complexation to the probe has no effect on the quantum yield; however, increases in the dye content resulted in partial quenching. The potential of the new nanoprobe, G6-(Cy5.5)(1.25)(1B4M-Gd)(145), as a dual modality imaging agent was demonstrated in vivo by the efficient visualization of sentinel lymph nodes in mice by both MRI and fluorescence imaging modalities.
Medical subject headings
- Dendrimers
- Fluorescence
- Gadolinium
- Magnetic Resonance Imaging
- Nanostructures
- Tomography