Hepatocyte growth factor: new arsenal in the fights against renal fibrosis?
review · Level V
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Abstract
Hepatocyte growth factor (HGF) has emerged as a potent, endogenous antifibrotic factor that shows an impressive efficacy in ameliorating tissue fibrosis in a wide variety of animal models. Herrero-Fresneda et al. provide new evidence demonstrating that intramuscular injection of HGF gene reduces mortality, inflammation, and renal fibrosis in chronic allograft nephropathy.
Medical subject headings
- Genetic Therapy
- Hepatocyte Growth Factor
- Kidney Failure, Chronic