Flipping riboswitches.
review · Level V
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Abstract
Riboswitches are common cis-acting regulatory elements in bacteria. They are made of nascent RNA that changes its conformation in response to direct binding of cognate metabolites. The publication of five high-resolution crystal structures provides a comprehensive view of how riboswitches sense their ligands and points to new challenges in this emerging field.
Medical subject headings
- Bacteria
- RNA, Bacterial
- Regulatory Elements, Transcriptional