OPA1 and PARL keep a lid on apoptosis.
review · Level V
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Abstract
A change in the shape of mitochondrial cristae must take place to attain rapid and complete release of cytochrome c during apoptosis. In this issue of Cell, Cipolat et al. and Frezza et al. (2006) show that a rhomboid intramembrane protease PARL and a dynamin-related protein OPA1 are critical regulators of cristae remodeling.
Medical subject headings
- Apoptosis
- GTP Phosphohydrolases
- Metalloproteases
- Mitochondria
- Mitochondrial Membranes
- Mitochondrial Proteins