p53 and metabolism: Inside the TIGAR.
review · Level V
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Abstract
The p53 tumor suppressor pathway coordinates DNA repair, cell-cycle arrest, apoptosis, and senescence to preserve genomic stability and prevent tumor formation. The discovery of three new target genes for p53 reveals unexpected functions for this tumor suppressor in the regulation of glucose metabolism and autophagy.
Medical subject headings
- Autophagy
- Cell Transformation, Neoplastic
- Energy Metabolism
- Tumor Suppressor Protein p53