Are mouse telomeres going to pot?
review · Level V
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- Record sourced from PubMed, PMID 16839874.
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Abstract
Pot1 is a conserved single-stranded DNA binding protein with crucial functions in the protection of telomeres and maintenance of their length. In this issue of Cell, two papers (Hockemeyer et al., 2006; Wu et al., 2006) examine the roles of murine Pot1 homologs and describe intriguing new insights into how cells protect their chromosome ends from DNA-repair activities.
Medical subject headings
- DNA
- DNA Damage
- DNA Repair
- DNA-Binding Proteins
- Telomere