A unique and universal molecular barcode array.
basic_science · Level V
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- Record sourced from PubMed, PMID 16862133.
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Abstract
Molecular barcode arrays allow the analysis of thousands of biological samples in parallel through the use of unique 20-base-pair (bp) DNA tags. Here we present a new barcode array, which is unique among microarrays in that it includes at least five replicates of every tag feature. The use of smaller dispersed replicate features dramatically improves performance versus a single larger feature and allows the correction of previously undetectable hybridization defects.
Medical subject headings
- DNA Probes
- Expressed Sequence Tags
- In Situ Hybridization, Fluorescence
- Molecular Probe Techniques
- Sequence Alignment
- Sequence Analysis, DNA