Circadian rhythmicity by autocatalysis.
basic_science · Level V
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- Record sourced from PubMed, PMID 16863394.
- Also identified by PMC identifier 1523307.
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Abstract
The temperature compensated in vitro oscillation of cyanobacterial KaiC phosphorylation, the first example of a thermodynamically closed system showing circadian rhythmicity, only involves the three Kai proteins (KaiA, KaiB, and KaiC) and ATP. In this paper, we describe a model in which the KaiA- and KaiB-assisted autocatalytic phosphorylation and dephosphorylation of KaiC are the source for circadian rhythmicity. This model, based upon autocatalysis instead of transcription-translation negative feedback, shows temperature-compensated circadian limit-cycle oscillations with KaiC phosphorylation profiles and has period lengths and rate constant values that are consistent with experimental observations.
Medical subject headings
- Bacterial Proteins
- Biological Clocks
- Circadian Rhythm
- Cyanobacteria
- Periodicity