Approach to salvage antiretroviral therapy in heavily antiretroviral-experienced HIV-positive adults.
review · Level V
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- Record sourced from PubMed, PMID 16870528.
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Abstract
Despite dramatic declines in HIV-associated morbidity and mortality as a result of highly active antiretroviral therapy, management of heavily treatment-experienced patients remains complex and challenging. Treatment response rates with subsequent antiretroviral regimens are lower than with initial antiretroviral therapy. Additionally, increased mortality has been associated with multidrug-resistant HIV. We review data relevant to management of such patients and offer a systematic approach to constructing a salvage antiretroviral regimen.
Medical subject headings
- Antiretroviral Therapy, Highly Active
- Drug Resistance, Viral
- HIV Infections
- Virus Replication