Knocking down disease with siRNAs.

Dykxhoorn, Derek M; Lieberman, Judy · Cell · 2006

review · Level V

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Abstract

Knocking down expression of disease-related genes using small interfering RNAs (siRNAs) has potential for treating a variety of illnesses. This Essay will examine the opportunities for harnessing RNA interference (RNAi) for therapy, as well as the obstacles and possible ways to circumvent them.

Medical subject headings