MutLalpha: at the cutting edge of mismatch repair.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 16873053.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
The mismatch repair process corrects errors in newly synthesized DNA. In this issue, Modrich and colleagues (Kadyrov et al., 2006) show that a component of the human mismatch repair machinery, MutLalpha, has endonuclease activity. MutLalpha introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXOI to degrade the strand containing the mismatch.
Medical subject headings
- Base Pair Mismatch
- DNA Repair
- MutS DNA Mismatch-Binding Protein