CK2 and PML: regulating the regulator.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 16873055.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
The PML protein induces senescence, and, upon oncogenic stress, its absence promotes cellular transformation. In this issue of Cell, Scaglioni et al. (2006) show that phosphorylation of PML by CK2, a kinase frequently activated in human cancers, promotes PML degradation. Therefore, pharmacological inhibition of CK2-induced PML loss could be used to offset tumor establishment.
Medical subject headings
- Casein Kinase II
- Gene Expression Regulation, Neoplastic
- Genes, Tumor Suppressor
- Neoplasm Proteins
- Nuclear Proteins
- Transcription Factors
- Tumor Suppressor Proteins