FOXP3 and NFAT: partners in tolerance.
review · Level V
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Abstract
Regulatory T cells suppress autoimmune responses to self-antigens. Recent studies, including one in this issue of Cell (Wu et al., 2006), suggest that the ability of T cells to choose between launching a productive immune response, functional inactivation, or developing into regulatory T cells depends upon the interplay of the key transcriptional regulators FOXP3 and NFAT.
Medical subject headings
- Forkhead Transcription Factors
- Immune Tolerance
- NFATC Transcription Factors