Polymorphism in Sp1 recognition site of the EGF receptor gene promoter and risk of glioblastoma.
case_control · Level III
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Abstract
We investigated two polymorphisms of the epidermal growth factor receptor promoter as potential risk factors and prognostic markers for glioblastoma. The -216T allele (which results in a 30% higher activity) was more frequent in the patients compared with the control population (224/376 = 59.6% vs 165/352 = 46.8%; p = 0.0006) corresponding to an odd ratio of 1.67 (1.24; 2.25). A modest difference in median survival was also associated with the TT genotype.
Medical subject headings
- ErbB Receptors
- Glioblastoma
- Polymorphism, Genetic
- Promoter Regions, Genetic
- Sp1 Transcription Factor