Single-dose lopinavir-ritonavir acutely inhibits insulin-mediated glucose disposal in healthy volunteers.
rct · Level II
Where this comes from
- Record sourced from PubMed, PMID 16886163.
- Also identified by PMC identifier 3205942.
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Abstract
Previously, we found that 4 weeks of treatment with lopinavir-ritonavir did not decrease insulin sensitivity but did increase adiponectin levels. In the present study, a single dose of lopinavir-ritonavir decreases insulin sensitivity but does not alter adiponectin levels. Insulin resistance from protease inhibitors may decrease with prolonged use; an increase in adiponectin levels may mediate this effect.
Medical subject headings
- Anti-HIV Agents
- Blood Glucose
- Insulin
- Pyrimidinones
- Ritonavir