Immunologic diseases, anti-inflammatory drugs, and Parkinson disease: a case-control study.

Bower, J H; Maraganore, D M; Peterson, B J; Ahlskog, J E; Rocca, W A · Neurology · 2006

case_control · Level III

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Abstract

The authors studied the association of markers of inflammation with the later development of Parkinson disease (PD) using a case-control design (196 cases and 196 matched controls). The frequency of diseases of immediate-type hypersensitivity was significantly higher in cases than controls. In addition, cases used anti-inflammatory agents less frequently than controls (nonsignificant trend). The results may support the hypothesis that there is an inflammatory component in the pathogenesis of PD.

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