Progressive depletion of mtDNA in mitochondrial myopathy.
case_series · Level IV
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- Record sourced from PubMed, PMID 16894115.
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Abstract
The authors studied seven patients with mitochondrial DNA (mtDNA) myopathy. Over time, there was a progressive depletion of mtDNA, which preferentially affected wild-type mitochondrial genomes. This suggests that loss of wild-type mtDNA is a major feature of mtDNA myopathy, and preventing wild-type mtDNA depletion has treatment implications.
Medical subject headings
- DNA, Mitochondrial
- Gene Deletion
- Mitochondrial Myopathies