Lack of association of VEGF promoter polymorphisms with sporadic ALS.
case_control · Level III
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Abstract
The authors tested the association of three vascular endothelial growth factor (VEGF) promoter polymorphisms with sporadic ALS (SALS) to verify the results of a previous study and to investigate their modifier effects on the subphenotypes of SALS in a large family-based and case-control cohort of North American white subjects (N = 1,603). They did not find any association of the VEGF promoter polymorphisms with SALS or its subphenotypes, suggesting that they do not have a direct causal role in ALS.
Medical subject headings
- Amyotrophic Lateral Sclerosis
- Polymorphism, Genetic
- Promoter Regions, Genetic
- Vascular Endothelial Growth Factor A