Diffusion tensor MRI shows abnormal brainstem crossing fibers associated with ROBO3 mutations.
case_report · Level V
Where this comes from
- Record sourced from PubMed, PMID 16894121.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Horizontal gaze palsy with progressive scoliosis (HGPPS) is caused by mutations in the ROBO3 gene, critical for the crossing of long ascending medial lemniscal and descending corticospinal tracts in the medulla. Diffusion tensor imaging in a patient with HGGPS revealed the absence of major pontine crossing fiber tracts and no decussation of the superior cerebellar peduncles. Mutations in the ROBO3 gene lead to a widespread lack of crossing fibers throughout the brainstem.
Medical subject headings
- Brain Diseases
- Brain Stem
- Genetic Predisposition to Disease
- Receptors, Immunologic