The effect of APOE genotype on clinical phenotype in Alzheimer disease.
cross_sectional · Level IV
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Abstract
The authors classified 100 patients with Alzheimer disease (AD) as presenting with a memory or nonmemory phenotype. APOE genotype was determined. There was an association between APOE-epsilon4 and clinical phenotype (odds ratio = 3.0; 95% CI: 1.2 to 7.8), suggesting that two subtypes of AD can be identified. The typical amnestic phenotype seems to be promoted by the APOE-epsilon4 allele, whereas the atypical nonmemory phenotype occurs in the absence of the APOE-epsilon4 allele.
Medical subject headings
- Alzheimer Disease
- Apolipoproteins E
- Genetic Predisposition to Disease