Pleural malignant solitary fibrous tumor with sarcomatous overgrowth showing PDGFRbeta mutation.
case_report · Level V
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Abstract
Pleural malignant solitary fibrous tumors (SFTs) are uncommon, and little is known about their histogenesis and molecular features. We report a case of pleural SFT with sarcomatous overgrowth that showed expression for PDGFRbeta and a missense mutation on exon 18 of the PDGFRbeta gene. The involvement of the PDGFRbeta gene in SFT is compatible with a pericytic derivation, also supporting a possible role of this tyrosine kinase in malignant transformation and in the adoption of novel molecular therapies.
Medical subject headings
- DNA, Neoplasm
- Mutation
- Neoplasms, Fibrous Tissue
- Pleural Neoplasms
- Receptor, Platelet-Derived Growth Factor beta
- Sarcoma