ErbB2 makes beta 4 integrin an accomplice in tumorigenesis.
basic_science · Level V
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Abstract
Integrins modulate signaling by growth factor receptors, but their role during tumorigenesis is not clear. Guo et al. (2006) now demonstrate that alpha 6 beta 4 integrin cooperates with ErbB2 in the formation of mammary tumors and discover distinct pathways that regulate cellular proliferation and adhesion downstream of the ErbB2-integrin complex.
Medical subject headings
- Carcinoma
- Cell Transformation, Neoplastic
- Integrin alpha6beta4
- Erb-b2 Receptor Tyrosine Kinases