A kinase gets caspases into shape.
basic_science · Level V
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Abstract
Two new papers (Kuranaga et al., 2006; Oshima et al., 2006) describe a previously uncharacterized Drosophila kinase (DmIKK epsilon) that regulates the abundance of DIAP1, a protein best known for its ability to inhibit apoptosis. However, DmIKK epsilon-mediated degradation of DIAP1 does not regulate apoptosis as might be predicted but instead regulates actin dynamics, cell morphology, and the differentiation of sensory organ precursor cells.
Medical subject headings
- Apoptosis
- Caspases
- Cell Differentiation
- Drosophila Proteins
- Inhibitor of Apoptosis Proteins
- Phosphotransferases
- Sense Organs