Histopathologic findings in primary erythromelalgia are nonspecific: special studies show a decrease in small nerve fiber density.

Davis, Mark D P; Weenig, Roger H; Genebriera, Joseph; Wendelschafer-Crabb, Gwen; Kennedy, William R; Sandroni, Paola · J Am Acad Dermatol · 2006

case_series · Level IV

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Abstract

The histopathology of primary erythromelalgia has been poorly characterized. A total of 33 skin biopsy specimens from 29 patients with a diagnosis of primary erythromelalgia were re-examined. Histopathologic findings were nonspecific. Vascular thrombi were not identified. A relative decrease in small nerve fiber density was noted in specimens from 13 of 16 patients.

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