Koebnerizing sclerodermatous graft-versus-host disease caused by donor lymphocyte infusion and interferon-alpha.
case_report · Level V
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- Record sourced from PubMed, PMID 16911292.
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Abstract
Graft-versus-host disease (GvHD) is a common sequel to allogeneic bone marrow transplants, which may be accompanied by desirable graft-versus-tumour effects. Sclerodermatous GvHD is a rare subtype that is very difficult to treat. We report the first case of sclerodermatous GvHD as part of the Koebner phenomenon. We propose that donor lymphocyte infusion and interferon-alpha were involved in the pathogenesis of this case.
Medical subject headings
- Antineoplastic Agents
- Graft vs Host Disease
- Interferon-alpha
- Lymphocyte Transfusion
- Scleroderma, Localized