Pilot clinical trial of gabapentin to decrease postoperative delirium in older patients.
rct · Level II
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- Record sourced from PubMed, PMID 16914695.
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Abstract
In this randomized pilot clinical trial, the authors tested the hypothesis that using gabapentin as an add-on agent in the treatment of postoperative pain reduces the occurrence of postoperative delirium. Postoperative delirium occurred in 5/12 patients (42%) who received placebo vs 0/9 patients who received gabapentin, p = 0.045. The reduction in delirium appears to be secondary to the opioid-sparing effect of gabapentin.
Medical subject headings
- Amines
- Cyclohexanecarboxylic Acids
- Delirium
- Neurosurgical Procedures
- Postoperative Pain
- Premedication
- gamma-Aminobutyric Acid