Favourable outcome of progressive multifocal leucoencephalopathy in two patients with dermatomyositis.
case_report · Level V
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- Record sourced from PubMed, PMID 16914758.
- Also identified by PMC identifier 2077730.
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Abstract
Progressive multifocal leucoencephalopathy (PML), a demyelinating disease caused by the JC virus (JCV), occurs in immunosuppressed patients and carries a poor prognosis. A favourable outcome is reported in two patients with PML and dermatomyositis. Immunosuppressive drugs were stopped in patient 1 but could only be partially tapered in patient 2. The JCV-specific CD8+ T cell response was strong in patient 1 and weak in patient 2. Both were treated with cytosine-arabinoside, and patient 2 was also treated with mirtazapine, a 5HT2A receptor antagonist. Combination of these drugs might be helpful to treat HIV-negative patients with PML.
Medical subject headings
- Dermatomyositis
- Immunosuppressive Agents
- Leukoencephalopathy, Progressive Multifocal