Matrix control of stem cell fate.
review · Level V
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Abstract
A key challenge in stem cell research is to learn how to direct the differentiation of stem cells toward specific fates. In this issue of Cell, Engler et al. (2006) identify a new factor regulating stem cell fate: the elasticity of the matrix microenvironment. By changing the stiffness of the substrate, human mesenchymal stem cells could be directed along neuronal, muscle, or bone lineages.
Medical subject headings
- Cell Differentiation
- Extracellular Matrix
- Mesenchymal Stem Cells