ZOning out tight junctions.
editorial · Level V
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- Record sourced from PubMed, PMID 16923383.
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Abstract
The tight junction is an intricate seal between adjoining epithelial cells that also separates the apical and basolateral membranes within these cells. A paper in this issue of Cell by Umeda et al. (2006) demonstrates that loss of the ZO scaffolding proteins prevents the formation of tight junctions but surprisingly does not perturb apico-basal polarity.
Medical subject headings
- Cell Polarity
- Membrane Proteins
- Phosphoproteins
- Protein Isoforms
- Tight Junctions