When it comes to decisions, myeloid progenitors crave positive feedback.

Muzzey, Dale; van Oudenaarden, Alexander · Cell · 2006

editorial · Level V

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Abstract

Positive feedback is a ubiquitous feature of networks that establish and maintain cellular decisions. In this issue of Cell, Laslo et al. (2006) demonstrate how a feedback loop comprised of two mutual repressors regulates the differentiation of myeloid progenitors into either macrophages or neutrophils.

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