Smith-Magenis syndrome: a case report of improved sleep after treatment with beta1-adrenergic antagonists and melatonin.
case_report · Level V
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Abstract
This report describes the case of a 4-year-old boy diagnosed with Smith-Magenis syndrome in whom treatment with a beta(1)-adrenergic antagonist in the morning (to suppress the diurnal melatonin secretion) and melatonin in the evening (to generate a nocturnal peak of melatonin) improved his sleep quality, evaluated by polysomnographic studies.
Medical subject headings
- Acebutolol
- Adrenergic beta-Antagonists
- Antioxidants
- Chronotherapy
- Melatonin
- Sleep Disorders, Circadian Rhythm