Staphylococcus aureus nasal carriage is associated with glucocorticoid receptor gene polymorphisms.
case_control · Level III
Where this comes from
- Record sourced from PubMed, PMID 16941349.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
The aim of this study was to determine whether polymorphisms of the glucocorticoid receptor gene, influencing glucocorticoid sensitivity, are associated with persistent nasal carriage of Staphylococcus aureus. Two nasal swab cultures were obtained from each of 2,929 participants. Subjects were classified as persistent carriers (n=563) if both cultures were positive. GG homozygotes of the exon 9beta polymorphism were associated with a 68% reduced risk of persistent S. aureus nasal carriage, whereas carriers of the codon 23 lysine allele displayed an 80% increased risk. Thus, genotype-dependent variation in the sensitivity to glucocorticoids is associated with tolerance toward staphylococcal nasal colonization.
Medical subject headings
- Carrier State
- Nasal Cavity
- Receptors, Glucocorticoid
- Staphylococcal Infections
- Staphylococcus aureus