POLG1 in idiopathic Parkinson disease.
case_control · Level III
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- Record sourced from PubMed, PMID 16943369.
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Abstract
We studied POLG1 in 140 UK patients with idiopathic Parkinson disease (PD) and 279 Italian patients with PD and compared them to a UK control group (n = 207) and an Italian control group (n = 285). Our observations do not support a role for common POLG1 genetic variants in PD and indicate that dominant POLG1 mutations are a rare cause of parkinsonism in the general population.
Medical subject headings
- DNA-Directed DNA Polymerase
- Genetic Predisposition to Disease
- Mutation
- Parkinson Disease
- Polymorphism, Genetic