Insulin biosynthesis: the IREny of it all.
review · Level V
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Abstract
Recent studies have shown that the unfolded protein response (UPR) is essential for the survival of insulin-producing beta cells. Work in this issue of Cell Metabolism (Lipson et al., 2006) identifies a novel role for UPR activation in beta cell function by demonstrating that the UPR effector IRE1 is a positive regulator of glucose-stimulated proinsulin biosynthesis.
Medical subject headings
- Endoribonucleases
- Glucose
- Insulin
- Insulin-Secreting Cells
- Membrane Proteins
- Protein Folding
- Protein Serine-Threonine Kinases