Xenobiotic receptor meets NF-kappaB, a collision in the small bowel.
review · Level V
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Abstract
It has long been appreciated that inflammation and infection reduce drug metabolism and that exposure to drug metabolism-inducing xenobiotics can impair immune function. A new study reveals the mutual repression between the xenobiotic nuclear receptor PXR/SXR and NF-kappaB signaling pathways, providing a molecular mechanism linking xenobiotic metabolism and inflammation (Zhou et al.,).
Medical subject headings
- Immune Tolerance
- Inflammation
- Intestine, Small
- NF-kappa B
- Receptors, Steroid
- Xenobiotics