Unique expression of human papilloma virus type 5 and type 16 in esophageal squamous cell carcinoma-a case report.
case_report · Level V
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Abstract
The role of human papilloma virus (HPV) in esophageal cancers from the low-incidence area (Western population) is unclear. We report a case of esophageal squamous papillomatosis associated with underlying esophageal squamous cell carcinoma (OSCC). The esophagectomy specimen confirmed presence of HPV-5 and HPV-16 suggesting a viral etiology. The significance of this dual infection is not known, but it suggests that esophageal papillomatosis is premalignant and should receive regular endoscopic follow-up. This is the first report of both HPV-5 and HPV-16 DNA detected in an esophageal cancer occurring in the Western population.
Medical subject headings
- Carcinoma, Squamous Cell
- DNA, Viral
- Esophageal Neoplasms
- Papilloma
- Papillomaviridae