Targeting protein stability with a small molecule.
basic_science · Level V
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- Record sourced from PubMed, PMID 16959558.
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Abstract
Both genetic approaches and small-molecule inhibitors can be used to perturb protein function. Banaszynski et al. (2006) now describe a strategy to regulate the stability of a target protein, in which specificity is provided by a genetically encoded tag and temporal control is imparted by a small molecule.
Medical subject headings
- Proteasome Endopeptidase Complex
- Recombinant Fusion Proteins
- Tacrolimus Binding Protein 1A
- Tacrolimus Binding Proteins