Signaling by transmembrane proteins shifts gears.
basic_science · Level V
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Abstract
The HAMP domain is present in a large number of transmembrane proteins in prokaryotes including histidine kinases, adenylyl cyclases, chemotaxis receptors, and phosphatases. In this issue of Cell, Hulko et al. (2006) report the NMR structure of a HAMP domain and present data suggesting that it transduces signals through a simple rotation of its four-helix parallel coiled coil.
Medical subject headings
- Archaeal Proteins
- Archaeoglobus fulgidus
- Membrane Proteins
- Signal Transduction