Oscillatory regulation of Hes1: Discrete stochastic delay modelling and simulation.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 16965175.
- Also identified by PMC identifier 1560403.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Discrete stochastic simulations are a powerful tool for understanding the dynamics of chemical kinetics when there are small-to-moderate numbers of certain molecular species. In this paper we introduce delays into the stochastic simulation algorithm, thus mimicking delays associated with transcription and translation. We then show that this process may well explain more faithfully than continuous deterministic models the observed sustained oscillations in expression levels of hes1 mRNA and Hes1 protein.
Medical subject headings
- Computer Simulation
- Gene Expression Regulation
- Homeodomain Proteins
- Models, Biological