Atypical cutaneous leishmaniasis in two patients receiving low-dose methotrexate.
case_report · Level V
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Abstract
Cutaneous leishmaniasis is a protozoan disease that has high morbidity. There have been increasing reports of leishmaniasis in patients with an underlying immunosuppressed state. We present two cases of cutaneous leishmaniasis caused by Old World species in patients on methotrexate therapy. We postulate that the T-cell-mediated response to leishmaniasis infection could be modulated by methotrexate and may render an immunosuppressed individual more susceptible to developing clinical disease.
Medical subject headings
- Immunosuppressive Agents
- Leishmaniasis, Cutaneous
- Methotrexate
- Opportunistic Infections