A novel autosomal dominant restless legs syndrome locus maps to chromosome 20p13.
basic_science · Level V
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Abstract
The authors investigated genetic factors contributing to restless legs syndrome (RLS) by performing a 10-cM genome-wide scan in a large French-Canadian pedigree. They detected an autosomal-dominant locus mapping to chromosome 20p13, with a maximum multipoint lod score of 3.86 at marker D20S849. This is the third reported autosomal-dominant locus for RLS and the first autosomal-dominant RLS locus in the French-Canadian population.
Medical subject headings
- Chromosome Mapping
- Chromosomes, Human, Pair 20
- Family Health
- Genetic Linkage
- Restless Legs Syndrome