Protease-modulated cellular uptake of quantum dots.
basic_science · Level V
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- Record sourced from PubMed, PMID 16968013.
- Also identified by PMC identifier 2553895.
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Abstract
Quantum dots (QDs) are often cell-impermeable and require transporters to facilitate crossing over cell membranes. Here we present a simple and versatile method that utilizes enzymes, matrix metalloprotease 2 (MMP-2) and MMP-7, to modulate the cellular uptake of QDs. QD-peptide conjugates could be efficiently taken up into cells after the MMP treatment. This enzyme-modulated cellular uptake of QDs may be applied to other nanoparticles for biological imaging and selective drug delivery into tumor cells.
Medical subject headings
- Coated Materials, Biocompatible
- Fibrosarcoma
- Matrix Metalloproteinase 2
- Matrix Metalloproteinase 7
- Molecular Probe Techniques
- Quantum Dots