Intricate knots in proteins: Function and evolution.
basic_science · Level V
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- Record sourced from PubMed, PMID 16978047.
- Also identified by PMC identifier 1570178.
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Abstract
Our investigation of knotted structures in the Protein Data Bank reveals the most complicated knot discovered to date. We suggest that the occurrence of this knot in a human ubiquitin hydrolase might be related to the role of the enzyme in protein degradation. While knots are usually preserved among homologues, we also identify an exception in a transcarbamylase. This allows us to exemplify the function of knots in proteins and to suggest how they may have been created.
Medical subject headings
- Cysteine Endopeptidases
- Evolution, Molecular