Anakinra prevents symptoms of familial cold autoinflammatory syndrome and Raynaud's disease.
case_report · Level V
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Abstract
Familial cold autoinflammatory syndrome (FCAS) is a rare, hereditary disorder characterized by cold-induced inflammation. We describe the successful longterm treatment of a patient with FCAS with anakinra, an interleukin 1 receptor antagonist (IL-1Ra). The remarkable response of FCAS and associated Raynaud's disease in this patient suggests that IL-1 is an important mediator of these inflammatory diseases. Our report supports increasing evidence that anakinra plays an important role in the treatment of select chronic inflammatory diseases.
Medical subject headings
- Cold Temperature
- Inflammation
- Interleukin 1 Receptor Antagonist Protein
- Raynaud Disease
- Receptors, Interleukin-1
- Vascular Diseases