Caspase-1 builds a new barrier to infection.
basic_science · Level V
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Abstract
Caspase-1 promotes both the maturation of proinflammatory cytokines and apoptosis in cells infected by certain pathogens. Work by now reveals a surprising new function for caspase-1: the stimulation of membrane biogenesis to repair damage caused by bacterial pore-forming toxins. Thus, caspase-1 may promote host cell survival as a means of resistance to pathogenic bacteria.
Medical subject headings
- Bacterial Infections
- Caspase 1
- Cell Membrane
- Immunity, Innate