CSF neurofilament levels: a potential prognostic marker in Guillain-Barré syndrome.
prospective_cohort · Level II
Where this comes from
- Record sourced from PubMed, PMID 17000982.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Long-term morbidity from Guillain-Barré syndrome (GBS) is caused by axonal damage. This prospective study demonstrated that neurofilaments (NfHs), a biomarker for axonal damage, were of prognostic value in GBS. CSF NfH levels correlated with the F score and Medical Research Council summed score and were higher in patients with neurophysiologic evidence of axonal degeneration compared to those without. Pathologically high CSF NfH levels (>0.73 ng/mL) predicted worse motor and functional outcome.
Medical subject headings
- Guillain-Barre Syndrome
- Neurofilament Proteins