Hormonal activity of AIMP1/p43 for glucose homeostasis.
basic_science · Level V
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- Record sourced from PubMed, PMID 17001013.
- Also identified by PMC identifier 1595450.
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Abstract
AIMP1/p43 is known as a cytokine working in the control of angiogenesis, inflammation, and wound healing. Here we report its enrichment in pancreatic alpha cells and glucagon-like hormonal activity. AIMP1 is secreted from the pancreas upon glucose starvation. Exogenous infusion of AIMP1 increased plasma levels of glucose, glucagon, and fatty acid, and AIMP1-deficient mice showed reduced plasma glucose levels compared with the wild-type mice under fasting conditions. Thus, AIMP1 plays a glucagon-like role in glucose homeostasis.
Medical subject headings
- Cytokines
- Glucose
- Homeostasis