FLASH is an essential component of Cajal bodies.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 17003126.
- Also identified by PMC identifier 1578500.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Cajal bodies are small nuclear organelles with a number of nuclear functions. Here we show that FLICE-associated huge protein (FLASH), originally described as a component of the apoptosis signaling pathway, is mainly localized in Cajal bodies and is essential for their structure. Reduction in FLASH expression by short hairpin RNA results in disruption of the normal architecture of the Cajal body and relocalization of its components. Because the function of FLASH in the apoptosis receptor signaling pathway has been strongly questioned, we have now identified a clear function for this protein.
Medical subject headings
- Apoptosis Regulatory Proteins
- Calcium-Binding Proteins
- Coiled Bodies