A paranasal tumor associated with tumor-induced osteomalacia.
case_report · Level V
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- Record sourced from PubMed, PMID 17003734.
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Abstract
Tumor-induced osteomalacia (TIO) is an extremely rare paraneoplastic syndrome associated with mesenchymal tumors in the craniofacial region. We treated a 24-year-old Japanese woman with paranasal sinus tumor and a low serum phosphate level who presented with nasal obstruction and systemic bone fractures. Serum fibroblast growth factor 23 (FGF-23) was measured before and after surgery. After surgery, her symptoms were resolved and the serum phosphate and FGF-23 levels became normalized. FGF-23 is thought to be a useful diagnostic marker in patients with craniofacial tumors associated with multiple systemic fractures.
Medical subject headings
- Mesenchymoma
- Osteomalacia
- Paranasal Sinus Neoplasms
- Paraneoplastic Syndromes