Cargo takes control of endocytosis.
basic_science · Level V
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- Record sourced from PubMed, PMID 17018271.
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Abstract
Clathrin-mediated endocytosis is a major route for diverse cargo to enter the cellular endocytic pathway. New findings by Puthenveedu and von Zastrow (2006) suggest that certain cargo proteins, such as G protein coupled receptors that bind to PDZ domains, regulate their own targeting to a subset of clathrin-coated pits. Thus, cargo proteins may cause functional specialization of vesicle trafficking within the early endocytic pathway.
Medical subject headings
- Clathrin
- Endocytosis
- Transport Vesicles